"(With) a grain of salt," (or "a pinch of salt") in modern English, is an idiom which means to view something with skepticism, or to not take it literally.
Theories of the phrase's origin include Pliny the Elder's Naturalis Historia, regarding the discovery of a recipe for an antidote to a poison. In the antidote, one of the ingredients was a grain of salt. Threats involving the poison were thus to be taken "with a grain of salt," and therefore less serious.
The Latin phrase cum grano salis ("with a grain of salt") is not what Pliny wrote. It is constructed according to the grammar of modern European languages rather than Classical Latin. Pliny's actual words were addito salis grano ("add a grain of salt").
An alternative account says that the Roman general Pompey believed he could make himself immune to poison by ingesting small amounts of various poisons, and he took this treatment with a grain of salt to help him swallow the poison. In this version, the salt is not the antidote. It was taken merely to assist in swallowing the poison.
The Latin word salis means both "salt" and "wit," so that the Latin phrase "cum grano salis" could be translated as both "with a grain of salt" and "with a grain (small amount) of wit." 
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